5HT 1 - Product Overview

Basic Information Overview

• Category: Neurotransmitter receptor
• Use: Regulates serotonin signaling in the brain
• Characteristics: G-protein coupled receptor
• Package: Typically available as a purified protein or plasmid for research purposes
• Essence: Plays a crucial role in modulating mood, appetite, and sleep
• Packaging/Quantity: Available in various quantities depending on the supplier

Specifications

• Type: G-protein coupled receptor
• Molecular Weight: Approximately 45 kDa
• Isoforms: 5HT 1A, 5HT 1B, 5HT 1D, 5HT 1E, 5HT 1F

Detailed Pin Configuration

• 5HT 1A: Seven transmembrane domains with intracellular and extracellular loops
• 5HT 1B: Similar structure to 5HT 1A with slight variations in amino acid sequence
• 5HT 1D: Consists of seven transmembrane domains connected by three extracellular and three intracellular loops
• 5HT 1E: Structurally similar to 5HT 1D with minor differences in the third intracellular loop
• 5HT 1F: Shares structural homology with other 5HT 1 receptors but exhibits distinct ligand-binding properties

Functional Features

• Ligand Binding: Affinity for serotonin (5-hydroxytryptamine) and related agonists/antagonists
• Signal Transduction: Activation of G-proteins leading to downstream intracellular signaling cascades
• Regulation: Modulation of neurotransmitter release and neuronal excitability

Advantages and Disadvantages

Advantages

• Crucial role in regulating mood and emotional behavior
• Target for pharmacological interventions in psychiatric disorders
• Potential therapeutic target for anxiety and depression

Disadvantages

• Limited understanding of subtype-specific functions
• Challenges in developing selective ligands for individual subtypes
• Complex interplay with other neurotransmitter systems

Working Principles

5HT 1 receptors, upon binding with serotonin or synthetic ligands, initiate intracellular signaling pathways through G-protein coupling. This leads to modulation of neuronal activity and neurotransmitter release, ultimately influencing various physiological and behavioral processes.

Detailed Application Field Plans

• Neuropharmacology: Investigating the role of 5HT 1 receptors in psychiatric disorders and drug development
• Neurophysiology: Understanding the impact of 5HT 1 receptor activation on neuronal excitability and synaptic transmission
• Behavioral Neuroscience: Exploring the influence of 5HT 1 receptors on mood, anxiety, and stress responses

Detailed and Complete Alternative Models

• 5HT 2 Receptors: Another class of serotonin receptors with distinct signaling properties
• Dopamine Receptors: Implicated in similar neuropsychiatric conditions and behavioral regulation
• Adrenergic Receptors: Involved in modulating stress responses and emotional arousal

This comprehensive overview provides insights into the significance and functional aspects of 5HT 1 receptors, shedding light on their diverse applications and potential implications in neuroscience and pharmacology.

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